Usage Note
Affatto almost always appears in negative sentences: non capisco affatto (I don't understand at all). Used alone as a response, affatto! can mean 'not at all!' (like 'absolutely not'). A common learner trap: affatto on its own can sound like a strong denial, so context matters. Avoid the archaism of using it in positive sentences (once possible, now sounded odd in modern Italian).
Examples
"Non mi piace affatto questo posto."
Natural Translation
I don't like this place at all.
Literal Translation
Not to-me pleases at-all this place.
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